Wegovy 1mg (4 PENS)

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Wegovy (semaglutide) is a prescription-only, once-weekly injectable medication designed for chronic weight management in adults with obesity (BMI ≥30) or overweight (BMI ≥27) with conditions like hypertension or type 2 diabetes. The 0.5mg dose, administered via a prefilled pen, is the first maintenance dose following the 0.25mg initiation phase, enhancing weight loss while minimizing side effects. Developed by Novo Nordisk, it’s FDA-approved for weight loss, not for type 1 diabetes or use in children under 12.

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Mechanisms of Action
Semaglutide, a GLP-1 receptor agonist, mimics the incretin hormone, boosting insulin secretion during elevated glucose levels, slowing gastric emptying to reduce post-meal glucose spikes, and suppressing appetite through hypothalamic signaling. This reduces hunger and caloric intake, promoting fat loss. With a ~7-day half-life, the 0.5mg dose drives ~10% weight loss (20–25 lbs for a 200-lb person) over 20–24 weeks in STEP trials, alongside improved metabolic markers.

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Weight Loss: Achieves 9–12% body weight loss with a 1,200–1,800 kcal/day diet and exercise.

Appetite Control: Reduces cravings within 2–4 weeks, aiding dietary adherence.

Metabolic Improvement: Lowers blood pressure, triglycerides, and improves insulin sensitivity.

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Cardiovascular Health: Reduces risk of major cardiovascular events, per STEP 8 trial data.
Effects build toward higher doses for sustained results.

Dosage and Administration

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After 4 weeks at 0.25mg, inject 0.5mg weekly into the abdomen, thigh, or upper arm, rotating sites. Administer any time of day, with or without food. Escalate to 1mg after 4 weeks if prescribed. If a dose is missed, inject within 5 days or skip. Store pens refrigerated (36–46°F) or at room temperature (up to 86°F) for 28 days.

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Safety and Side Effects
Common side effects include nausea, diarrhea, and constipation (15–30%), typically decreasing over time. Serious risks include pancreatitis, gallbladder issues, and thyroid tumors (observed in rats). Hypoglycemia is rare but possible with diabetes drugs. Avoid in medullary thyroid carcinoma or MEN2 history. Monitor for severe abdominal pain or thyroid symptoms.