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NAD+ (Nicotinamide Adenine Dinucleotide) injections deliver a vital coenzyme directly into the bloodstream to replenish declining cellular levels, which drop by up to 50% every 20 years. Used in anti-aging, wellness, and addiction recovery, these subcutaneous or intramuscular shots bypass digestion for rapid absorption, supporting energy production, DNA repair, and cellular health.
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Mechanisms of Action
NAD+ is essential for mitochondrial energy production, transferring electrons in redox reactions to generate ATP. It activates sirtuins (e.g., SIRT1), longevity proteins that regulate gene expression, DNA repair, and apoptosis. NAD+ also supports PARP enzymes for DNA damage repair and enhances NAMPT activity for NAD+ recycling. By boosting NAD+, injections reduce oxidative stress, improve mitochondrial function, and slow cellular aging.
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Anti-Aging: Enhances cellular repair, potentially reducing wrinkles and improving skin elasticity.
Energy Boost: Increases ATP production, reducing fatigue and improving stamina.
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Cognitive Health: Supports neuronal function, improving memory and focus in early trials.
Addiction Recovery: Reduces cravings and withdrawal symptoms in alcohol and substance use disorders.
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Metabolic Health: Improves insulin sensitivity and fat metabolism in preliminary studies.
A 2020 pilot trial reported improved muscle function and cognition in older adults after NAD+ infusions.
Dosage and Administration
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Typical doses start at 50–100 mg subcutaneously weekly, increasing to 100–250 mg 1–3 times weekly over 4–8 weeks, up to 500 mg for intensive protocols. Injections target the abdomen, upper arm, or thigh, with sites rotated to avoid irritation. Reconstituted vials are stored at 36–46°F and expire 30 days after opening. Administered by professionals or self-injected at home with a prescription.
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Safety and Side Effects
Common side effects include injection site redness, bruising, or mild nausea. High doses may cause headaches or fatigue. Contraindicated in severe liver/renal impairment, cardiovascular disease, or recent cancer. No toxicity is reported at recommended doses, but long-term data is limited. Consult a healthcare provider.
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