Cheapest Tirzepatide​

Cheapest Tirzepatide​

Tirzepatide (Mounjaro, Zepbound) is a once-weekly injectable peptide developed by Eli Lilly for type 2 diabetes, weight loss, and moderate-to-severe obstructive sleep apnea (OSA). A dual GIP and GLP-1 receptor agonist, it’s FDA-approved for adults with type 2 diabetes (Mounjaro) and obesity/overweight with comorbidities (Zepbound, BMI ≥30 or ≥27). Available via prescription, it’s not for type 1 diabetes or children.

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Mechanisms of Action
Tirzepatide, a 39-amino-acid peptide with a C20 fatty diacid, enhances insulin secretion, reduces glucagon, slows gastric emptying, and suppresses appetite via GIP and GLP-1 receptor activation.

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Its higher GIP affinity and cAMP-biased GLP-1 signaling increase insulin sensitivity and fat metabolism, outperforming GLP-1-only agonists like semaglutide. SURMOUNT-5 trials showed 47% greater weight loss (20.2% vs. 13.7%) than semaglutide. It has a ~5-day half-life, allowing weekly dosing.

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Weight Loss: Achieves 15–20.9% body weight loss (30–50 lbs) at 5–15mg over 72 weeks with diet/exercise.

Glycemic Control: Lowers HbA1c by 1.6–2% in type 2 diabetes; 94% reduced diabetes risk in prediabetics.

Cardiometabolic Health: Reduces blood pressure, triglycerides, and cardiovascular risk (SURPASS-CVOT).

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OSA Improvement: Enhances sleep apnea outcomes in obese adults. Early insulin sensitivity improvements occur within 12 weeks.

Dosage and Administration

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Start at 2.5mg weekly for 4 weeks, escalating by 2.5mg every 4 weeks (e.g., 5mg, 7.5mg) up to 15mg, injected subcutaneously in the abdomen, thigh, or upper arm. Rotate sites; use any time of day. Store pens/vials refrigerated (36–46°F). If missed, inject within 4 days or skip.

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Safety and Side Effects
Common side effects include nausea, vomiting, and diarrhea (20–40%), dose-dependent. Serious risks: pancreatitis, gallbladder issues, thyroid C-cell tumors (rat data), and acute kidney injury from dehydration. Contraindicated in medullary thyroid carcinoma, MEN-2, or severe hypersensitivity. Avoid in pregnancy; use non-oral contraceptives during initiation/escalation.