Pt 141 nasal spray​

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PT-141 (Bremelanotide) Nasal Spray is a synthetic peptide designed to treat sexual dysfunction, including erectile dysfunction (ED) in men and hypoactive sexual desire disorder (HSDD) in women. Unlike PDE5 inhibitors (e.g., Viagra), it acts on melanocortin receptors (MC3R, MC4R) in the brain to enhance sexual arousal and desire. Available by prescription from compounding pharmacies like SweetSpot Labs, it offers a non-invasive alternative to injections.

 

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Mechanisms of Action
PT-141 stimulates melanocortin receptors, increasing dopamine release, which regulates libido and sexual motivation. It triggers nitric oxide release, relaxing penile muscles and improving blood flow for erections, while enhancing arousal in women. Nasal delivery ensures rapid absorption via the mucosal lining, with effects starting within 30–60 minutes and lasting several hours. Bioavailability is lower than injections, requiring higher doses (e.g., 7–15mg vs. 1mg injectable).

 

 

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Enhanced Libido: Boosts sexual desire in men and women, effective for HSDD and ED unresponsive to sildenafil.

 

Erectogenic Effects: Improves erection quality, with 33.5% success in ED patients vs. 8.5% placebo.

 

Mood and Energy: Elevates mood and vitality, enhancing intimate experiences.

 

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Non-Invasive: Needle-free administration suits those averse to injections.
Phase IIb trials show significant erectile function improvement at 12.5–15mg doses.

 

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Usage and Administration
Administer 1–2 sprays (2mg/mL, ~0.1mL/spray) per nostril 45 minutes before sexual activity, ideally on an empty stomach for optimal absorption. A 10mL bottle (~100 sprays) has a 30-day beyond-use date; store at room temperature, away from heat. Shake gently before use. Consult a provider for dosing, typically 7–15mg per use.

 

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Safety and Side Effects
Common side effects include nausea (up to 40%), nasal irritation, flushing, and headaches. Serious risks include transient blood pressure increases, contraindicating use in uncontrolled hypertension or with nitrates. Long-term safety is under study; not FDA-approved for nasal use (only Vyleesi injectable for HSDD). Avoid in pregnancy.

 

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Legal Status
Available by prescription; not FDA-approved for nasal delivery. Banned by WADA. Purchase from reputable sources like Empower Pharmacy.