Epitalon

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Epitalon, also known as Epithalon or Epithalamin, is a synthetic tetrapeptide (Ala-Glu-Asp-Gly, molecular formula C14H22N4O9) derived from the pineal gland’s natural polypeptide, epithalamin. Developed by Russian scientist Vladimir Khavinson, it’s studied for its anti-aging properties, primarily through telomerase activation, which elongates telomeres—protective DNA caps that shorten with age, limiting cell division.

 

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stimulates telomerase, an enzyme that adds DNA to telomeres, extending cell lifespan by enabling more divisions. In vitro studies show it surpasses the Hayflick limit in human fibroblast cultures, extending proliferation from 34 to over 44 passages. It also enhances melatonin production, regulating circadian rhythms, and boosts antioxidant enzymes like superoxide dismutase, reducing oxidative stress. Additionally,  may influence epigenetic processes, upregulating neurogenic genes (e.g., Nestin, GAP43) and inhibiting tumor-related proteins like MMP9.

 

epitalon peptide benefits

 

Anti-Aging: Lengthens telomeres, potentially delaying age-related diseases.

 

Longevity: Animal studies show increased lifespan in mice, rats, and fruit flies.

 

Antioxidant Effects: Reduces reactive oxygen species (ROS) and lipid oxidation.

 

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Sleep Regulation: Improves melatonin levels, normalizing circadian rhythms.

 

Immune Support: Enhances T-cell function and interleukin-2 synthesis.

 

Eye Health: Shows promise in retinitis pigmentosa, with 90% of treated patients reporting clinical improvement.

 

epitalon benefits

 

Cancer Prevention: Reduces spontaneous tumors and metastases in mice.

Dosage and Administration
Typical doses range from 5–10 mg daily via subcutaneous or intramuscular injections for 10–20 days, followed by a break. Nasal sprays (15–30 mg/day) or oral forms (400–600 mg/day) are less effective due to digestive breakdown. Consult a healthcare provider for tailored dosing.

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