Wegovy 0.25 mg (4 PENS)

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Wegovy (semaglutide) is a prescription-only, once-weekly injectable medication for chronic weight management in adults with obesity (BMI ≥30) or overweight (BMI ≥27) with weight-related comorbidities (e.g., hypertension, type 2 diabetes). The 0.25mg dose, delivered via a prefilled pen, is the starting dose to minimize side effects during initiation. Developed by Novo Nordisk, it’s FDA-approved for weight loss and not for type 1 diabetes or children under 12.

 

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Mechanisms of Action
Semaglutide, a GLP-1 receptor agonist, mimics the incretin hormone, stimulating insulin release during high blood glucose, slowing gastric emptying, and suppressing appetite via hypothalamic signaling.

 

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This reduces caloric intake and promotes fat loss. With a ~7-day half-life, the 0.25mg dose initiates these effects, with STEP trials showing 5–8% body weight loss (10–16 lbs) over 16–20 weeks when titrated, alongside modest glycemic improvements.

 

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Weight Loss: Achieves 5–8% body weight loss at early doses with diet and exercise.

 

Appetite Suppression: Reduces hunger within 2–4 weeks, aiding 1,200–1,800 kcal/day diets.

 

Metabolic Health: Improves insulin sensitivity, blood pressure, and lipids.

 

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Cardiovascular Benefits: Lowers heart attack/stroke risk in at-risk adults, per STEP 8 data.
Early effects support progression to higher doses (up to 2.4mg).

Dosage and Administration

 

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Administer 0.25mg weekly for 4 weeks, injected subcutaneously into the abdomen, thigh, or upper arm, rotating sites. Use any time of day, with or without food. Escalate to 0.5mg after 4 weeks, as prescribed. If a dose is missed, inject within 5 days or skip. Store pens refrigerated (36–46°F) or at room temperature (up to 86°F) for 28 days.

 

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Safety and Side Effects
Common side effects include nausea, diarrhea, and constipation (15–25%), often temporary. Serious risks include pancreatitis, gallbladder disease, and thyroid tumors (rat data).

 

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Hypoglycemia is rare but possible with diabetes medications. Avoid in medullary thyroid carcinoma or MEN2 history. Monitor for severe abdominal pain or thyroid symptoms (e.g., neck lumps).