Wegovy 0.5 (4 PENS)

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Wegovy (semaglutide) is a prescription-only, once-weekly injectable medication for chronic weight management in adults with obesity (BMI ≥30) or overweight (BMI ≥27) with weight-related comorbidities (e.g., hypertension, type 2 diabetes). The 0.5mg dose, delivered via a prefilled pen, is the first maintenance dose after the 0.25mg starter dose, balancing efficacy and tolerability. Developed by Novo Nordisk, it’s FDA-approved for weight loss and not for type 1 diabetes or children under 12.

 

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Mechanisms of Action
Semaglutide, a GLP-1 receptor agonist, mimics the incretin hormone, enhancing insulin release during high blood glucose, slowing gastric emptying to stabilize post-meal glucose, and suppressing appetite via hypothalamic pathways. This promotes fat loss by reducing caloric intake. With a ~7-day half-life, the 0.5mg dose drives significant effects, with STEP trials showing 8–12% body weight loss (16–24 lbs) over 20–24 weeks when titrated, plus improved glycemic control.

 

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Weight Loss: Achieves 8–12% body weight loss with diet and exercise over 5–6 months.

 

Appetite Suppression: Reduces hunger within 2–4 weeks, supporting 1,200–1,800 kcal/day diets.

 

Metabolic Health: Enhances insulin sensitivity, lowers blood pressure, and improves lipids.

 

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Cardiovascular Benefits: Reduces heart attack/stroke risk in at-risk adults, per STEP 8 data.
Benefits strengthen as patients progress to higher doses.

Dosage and Administration

 

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After 4 weeks at 0.25mg, administer 0.5mg weekly, injected subcutaneously into the abdomen, thigh, or upper arm, rotating sites. Use any time of day, with or without food. Escalate to 1mg after 4 weeks if prescribed. If a dose is missed, inject within 5 days or skip. Store pens refrigerated (36–46°F) or at room temperature (up to 86°F) for 28 days.

 

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Safety and Side Effects
Common side effects include nausea, diarrhea, and constipation (20–30%), often subsiding. Serious risks include pancreatitis, gallbladder disease, and thyroid tumors (rat data). Hypoglycemia is rare but possible with diabetes medications. Avoid in medullary thyroid carcinoma or MEN2 history. Monitor for severe abdominal pain or thyroid symptoms (e.g., neck lumps).